Furthermore, linear regression models assessing the relationship between total IgG4 levels and disease status compared to non-disease controls showed no significant association with either AChR-MG (β = 0.282, p = 0.256) or MuSK-MG (β = 0.331, p = 0.140; Supplementary Table 3a and Supplementary Figure 9). This evidence concerns the gene MUSK and myasthenia gravis.