Benefiting from this, IR‐TAM@Alb nanoparticles more effectively induced mitochondria dysfunction to reverse tumor hypoxia, inhibit TGF‐β secretion, and depress PD‐L1 expression at a relatively lower dosage of 4 μm in vitro, while the dosage was about 30 μm for free TAM or TAM@Alb group (Figure 3). This evidence concerns the gene CD274 and neoplasm.