ALB and neoplasm: To further solve the defects of TAM in lacking tumor‐targeting capacity, we chemically conjugated OXPHOS disruption anti‐tumor agent TAM with tumor/fibrosis dual‐targeting heptamethine cyanine dye IR‐68 to establish a novel TAM derivate named IR‐TAM and then further self‐assembled with Alb to form IR‐TAM@Alb nanoparticles.