As we proved in this study, IR‐TAM@Alb nanoparticles could also selectively accumulate in the area of RIPF to prevent or depress the radiation‐induced fibroblast activation by inhibiting collagen generation, α‐SMA deposition, and fibronectin production in Balb/C mice, which was also used for 4T1 tumor establishment (Figure 7). This evidence concerns the gene ACTA1 and neoplasm.