Then, IR‐TAM@Alb nanoparticles combination therapy with RT rather than RT alone or IR‐TAM@Alb nanoparticles itself most effectively converted cold tumors to hot ones via generation amounts of DNA damage and T cell infiltration in both bladder cancers and breast cancers to inhibit local and abscopal tumor growth, as well as preventing tumor metastasis. The gene discussed is ALB; the disease is breast cancer.