By doing this, IR‐TAM@Alb nanoparticles rather than TAM possessed ideal tumor targeting capacity to depress PD‐L1 and TGF‐β expression (TAM 30 μm versus IR‐TAM 4 μm), which then sensitized tumor RT by enhancing DNA damage, amplifying T cell infiltration, and preventing the possible acquired immune resistance induced by RT. This evidence concerns the gene TGFB1 and neoplasm.