Then, IR‐TAM@Alb nanoparticles combination therapy with RT rather than RT alone or IR‐TAM@Alb nanoparticles itself most effectively converted cold tumors to hot ones via generation amounts of DNA damage and T cell infiltration in both bladder cancers and breast cancers to inhibit local and abscopal tumor growth, as well as preventing tumor metastasis. This evidence concerns the gene ALB and urinary bladder cancer.