As is well known, some heptamethine cyanine dyes possessed ideal tumor mitochondria targeting capacity.[20] Besides, it was also newly revealed that some heptamethine cyanine dye could also selectively accumulate at the fibrosis area.[21] Moreover, conjugating TAM with mitochondria‐targeting agents may also decrease the dosage of TAM needed to induce mitochondria dysfunction.[16] Thus, conjugating TAM with heptamethine cyanine dye may be used as a tumor and fibrosis dual‐targeting and co‐therapy agent for effective RT and fibrosis prevention by PD‐L1 and TGF‐β depression. Here, TGFB1 is linked to neoplasm.