By doing this, IR‐TAM@Alb nanoparticles effectively reversed tumor hypoxia, depressed PD‐L1 expression, and inhibited TGF‐β secretion at a relatively lower dosage by inducing mitochondria dysfunction when compared with free TAM or TAM@Alb (TAM 30 μm versus IR‐TAM 4 μm). The gene discussed is ALB; the disease is neoplasm.