EGFR and colorectal carcinoma: In our previous review [23], some non-coding RNAs (ncRNAs) can influence the malignant phenotype of CRC by regulating gene expression or the activity of certain signaling pathways such as RAS/RAF/MEK/MAPK or PI3K/AKT, thereby mediating anti-EGFR mAbs resistance [17, 24, 25].