A cohort study involving 54,123 Chinese individuals with an average age of 49.05±11.84 years and a follow-up of 11.3 years found that when the cumulative AIP level was higher than 0.28, the risk of ischemic stroke was 1.45 times higher than when it was lower than -0.50, making cumulative AIP an independent predictor of ischemic stroke [24]. Here, AIP is linked to ischemic stroke.