CAA = cerebral amyloid angiopathy; CERAD = Consortium to Establish a Registry for Alzheimer Disease; APOEε = apolipoprotein E; HLA-DRB1*04 = human leukocyte antigen DRB1*04 subtypes; GBA1 = glucocerebrosidase gene 1. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.