As previously described and confirmed by our study, early affected regions in AD exhibited similar Aβ- and p-tau- pathological loads in pure AD and mixed DLB + AD cases [4], while regions affected in more advanced disease stages [6], such as limbic regions for p-tau and cortical regions for Aβ pathology, were more heavily affected in pure AD cases [4, 82]. This evidence concerns the gene MAPT and Alzheimer disease.