NFKB1 and atherosclerosis: Here, we provided evidence that downregulation of miR-449a decreased lipid deposition, inflammatory cytokines as well as the number of macrophages and VECs but increased collagen accumulation and the number of VSMCs via targeting CEACAM1 to inhibit the NF-κB pathway, which is a canonical pro-inflammatory pathway involves in atherosclerosis [39–41].