JAK2 and neoplasm: Activation of the JAK2/STAT3 signaling pathway by IL-6 has been reported to mediate tumorigenesis via regulation of key cellular processes, including apoptosis, cycle progression, proliferation, invasion, migration, metastasis, angiogenesis, and tumor cell escape from the immune system [43], as well as involvement in cancer cachexia [44], and promoting the process of epithelial-mesenchymal transition (EMT) and stem cell-like features [45].