In systemic lupus erythematosus (SLE), lncRNA H19 is significantly upregulated and inhibits the proliferation of Treg cells and promotes the conversion of Treg cells to Tfh cells through the direct inhibition of IL-2 production, which results in immune dysregulation and exacerbates autoimmunity [49]. This evidence concerns the gene IL2 and systemic lupus erythematosus.