IL1R1 and amebiasis: While some significant GO terms were identified in female MIA offspring (‘Amoebiasis’, ‘Cytokine-cytokine receptor interaction’ and ‘Human T-cell leukemia virus 1 infection’), all were driven by the genes interleukin 1 receptor type 1 (Il1r1) and transforming growth factor beta 3 (Tgfb3) (Fig. 3c).