We established mouse PDAC cell lines (KPC-1) and CAF cells (mCAF1) from primary PDAC tumors of KrasG12D/+, Trp53R172H/+, and Pdx-1-Cre (KPC) mice [29–31] and established orthotopic syngeneic PDAC models to investigate tumor growth. Here, PDX1 is linked to neoplasm.