CD274 and non-small cell lung carcinoma: Liu et al. demonstrated that circIGF2BP3 upregulated PD-L1 in an OTUB1-dependent manner by sponging miR-328-3p and miR-3173-5p; accordingly, circIGF2BP3 inhibition sensitized NSCLC to anti-PD-1 blockade concomitant with increased activation of CTLs in vivo [117].