YAP1 and pancreatic ductal adenocarcinoma: Furthermore, USP10 desensitizes pancreatic ductal adenocarcinoma (PDAC) cells to NK cell-mediated cytotoxicity by deubiquitinating yes-associated protein 1 (YAP1, a core component of Hippo signaling) to transcriptionally upregulate both PD-L1 and galectin-9 (Gal-9) [23].