In conclusion, for the first time we emphasized and identified that circ_PPAPDC1A was significantly upregulated and exerts an oncogenic role in Osimertinib resistance of NSCLC by sponging miR-30a-3p to active IGF1R/PI3K/AKT/mTOR pathway in NSCLC. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.