KEGG pathway analysis revealed the top 10 pathways involved in CNC functions of these circRNAs were PPAR signaling pathway, malaria, rheumatoid arthritis, NF-kappa B signaling pathway, inflammatory mediator regulation of TRP channels, regulation of actin cytoskeleton, cytokine-cytokine receptor interaction, B cell receptor signaling pathway, vascular smooth muscle contraction, and fat digestion and absorption (Fig. 6B). This evidence concerns the gene PPARA and rheumatoid arthritis.