Conversely, HRH1, ITGB3, CCL20, MARCO, FFAR2, IL4R, CDKN1A, SLC11A2, ROS1, IL18, C5AR1, and GNA15 exhibited reduced methylation in most cancers (FDR ≤ 0.05, Fig. 1E). The gene discussed is CDKN1A; the disease is cancer.