In addition, identification of C2A-2B-3-4 of SMN1/2 was reported by another independent study39. C2A–2B–3–4 is predicted to interact with at least 16 miRNAs, three of which specifically target the backsplice junction (miR-130b-5p, miR-6812-3p, and miR-15b-3p) and two of which are associated with SMN-related biology and/or neurodegenerative diseases (miR-2110 and miR-510-3p)46. This evidence concerns the gene SMN1 and neurodegenerative disease.