RPS6KB1 and central nervous system cancer: To further confirm that YANK2 plays a role in promoting glioma growth through phosphorylation of p70S6K, H4 or U373 with YANK2, U87MG or Hs683 cells stably expressing shYANK2 were treated with the p70S6K inhibitor PF-4708671, and their growth ability was tested by plate cloning experiments.