Of the CMRs showing an increased |Δβadj| for PD status the increase was modest, with maximum increases of 0.0287 at MUC17 accounting for a G × E model with the SNP rs112404953 and gardening-level exposure, 0.0163 at SLITRK5 accounting for the G model of rs954384, 0.0114 at BBOX1 accounting for a G × E model with the SNP rs10742165 and gardening-level exposure, and 0.0104 at MIR7-3HG accounting for a G × E model with the SNP rs7257678 and gardening-level exposure; the remainder of increases were less than 0.01 (Supplementary Table 7). This evidence concerns the gene BBOX1 and Parkinson disease.