Conversely, males with PD had nonsignificant trends (padj > 0.05) toward decreased CD8+ and CD4+ naive T cell proportions and decreases in other lymphocytes and increases in neutrophils, more consistent with previously reported immune cell type changes in PD and with the cell type composition profiles we calculated in the three independent samples (Fig. 2b, Supplementary Fig. 1B)4,10,12. Here, CD8A is linked to Parkinson disease.