DENND2B and Parkinson disease: Aside from the replicated CMR genes, the full list of PD-associated CMRs in females from TERRE included additional genes which could have relevance for PD: CRTC1, which has been reported as differentially methylated in prefrontal cortex (PFC) neurons from PD patients and whose protein product is involved in mitochondrial biogenesis; SLC1A7, encoding a glutamate transporter; FXR2, whose protein product is involved in DNA damage response; and ST5, SNPs of which are associated with PD progression, and whose protein product is involved in endosomal trafficking56–59.