Despite the lack of overlap with previous EWAS in the blood of PD patients, several CMRs differentially methylated in the females analysis mapped to genes previously reported as differentially methylated in PFC neurons from PD patients (NAV2, CRTC1, NTSR1, ADARB2), and/or in brain tissue from PD patients (CACNA1H, differentially methylated in cingulate gyrus)17,56. This evidence concerns the gene NAV2 and Parkinson disease.