ACVR1C and Alzheimer disease: Taken together, results indicate that during periods in which hippocampus-dependent memory and LTP are impaired with age and in AD, Acvr1c is reduced in hippocampus and that conversely, enhancing ACVR1C through viral-mediated overexpression enables long-term memory formation and enhances synaptic plasticity in aging and 5xFAD mice.