Interrogating the genomic and/or transcriptomic landscape of 128 Vk*MYC MM samples representing 119 unique tumors from 41 de novo MM, 65 transplantable lines and 25 tumors capable of growing in vitro (Supplementary Fig. 1), we reveal that phenotypic similarities of the Vk*MYC mouse to human MM are driven by spontaneously acquired common genomic events, including NFkB activation, APOBEC mutational activity, driver gene mutations, aneuploidies and complex structural variants. This evidence concerns the gene NFKB1 and Miyoshi myopathy.