AICDA and Miyoshi myopathy: Looking at the Ig loci and AID-off target genes, we observed clear evidence of somatic hypermutation and SBS84 (AID, a mutational process usually undetectable in mutational signature genome wide analysis) and SBS9 involvement in all but five MM (Fig. 6B), confirmed by a comparative and focused analysis restricted to the clonal Ig genes in murine and human PCs (Fig. 6C).