SBS84 localized mutational activity and AID involvement was also observed across known AID off-target genes, similar to what has been reported in human MM, and implicated in the mutations affecting the driver genes: Dusp2, Pim1, H1f4/Hist1h1e, and H1f2/Hist1h1c (Supplementary Fig. 10). This evidence concerns the gene H1-2 and Miyoshi myopathy.