Positively selected genes currently not included in the catalogue of recurrent MM drivers included H1f2/Hist1h1c, Pten, and Tbsb4x. Additional non-synonymous SNVs were found in known human MM driver genes such as Nras, Kras, Cyld, Sp140, Rasa2, and Dis3, but at a lower frequency compared to human MM (Fig. 1A). Here, SP140 is linked to Miyoshi myopathy.