A total of 11 driver genes under positive selection were detected (q < 0.1; Fig. 1A, Supplementary Fig. 2B and Supplementary Data 4), six of which are related to known driver genes in MM (Dusp2, Trp53, Nfkbia, Pim1, Tent5c/Fam46c, H1f4/Hist1h1e). This evidence concerns the gene H1-4 and Miyoshi myopathy.