Unique to Vk*MYC MM is the hijacking of a murine-specific mutational process that utilizes the IAP transposable element to dysregulate Map3k14, Ltbr, Il6 and Ncor1, highlighting the central role of the NFkB, STAT3 and chromatin modifier pathways in MM pathogenesis. Here, NFKB1 is linked to Miyoshi myopathy.