To infer potential metabolic competitions within the TME, we revealed metabolic dependencies of different cellular subtypes, including OXPHOS (all the cells), glycolysis (basal-like and cycling cancer cells, memory B cells, CD8 + T cells, cycling T cells, monocyte and cycling myeloid), glutathione (CAFs and endothelial cells), and cytochrome P450 (CAFs, endothelial cells, and normal breast epithelial cell). Here, CD8A is linked to cancer.