Upon knockdown of the metabolic-related genes, we observed a decreased cell viability (evaluated by XTT cytotoxicity assay, Fig. 8a, b) and increased apoptosis (evaluated by caspase 3/7 assay, Fig. 8c, d and Supplementary Fig. 19c) of the tumor cells with the knocked-down genes compared to the control cells. Here, CASP3 is linked to neoplasm.