In a recent investigation, TREM2+SPP1+ macrophages in human fibrotic liver tissue were identified as scar-associated macrophages that could promote hepatic fibrosis.8 In the present study, we had identified MP2 marked SPP1, triggering receptor expressed on myeloid cells 2 (TREM2) and MM9 in human tendon adhesion tissue (Fig. 4b, c). This evidence concerns the gene SPP1 and Hepatic fibrosis.