For example, a positive association has been reported between FOLR2+ macrophages and cancer prognosis.43,60 In our study, by combining mouse tendon adhesion scRNA-seq, proteomics, immunofluorescence images, and in vitro cell experiments, we proposed that FOLR2+ macrophages could mitigate fibrosis through direct interaction with fibroblasts via pathways such as oxidative phosphorylation or MAPK signaling pathway and IGF1 was the possible ligand. This evidence concerns the gene FOLR2 and cancer.