For example, a positive association has been reported between FOLR2+ macrophages and cancer prognosis.43,60 In our study, by combining mouse tendon adhesion scRNA-seq, proteomics, immunofluorescence images, and in vitro cell experiments, we proposed that FOLR2+ macrophages could mitigate fibrosis through direct interaction with fibroblasts via pathways such as oxidative phosphorylation or MAPK signaling pathway and IGF1 was the possible ligand. The gene discussed is IGF1; the disease is cancer.