For example, RGCC was linked to renal fibrosis, while ACKR1+ ECs promoted pulmonary fibrosis.61,62 Besides, the similar profibrotic phenomenon of ACKR1+ ECs was also found in hepatic fibrosis.8 In our recent study, ACKR1+ ECs were identified as profibrotic clusters and further certification was performed. This evidence concerns the gene RGCC and renal fibrosis.