HDAC3 and rheumatoid arthritis: In PBMCs obtained from both RA patients and healthy individuals, as supported by Gillespie and colleagues through their 2012 study, the production of key inflammatory cytokines, such as IFNγ, TNF, and IL-6, was notably suppressed by TSA and MI192 (HDAC3 selective inhibitor) individually (Gillespie et al. 2012).