For this purpose, RA and AS patients and unrelated healthy controls were genotyped for two non-synonymous single nucleotide polymorphisms (SNPs): (I) a T to G substitution (rs396991) within the FCγR3A gene resulting in phenylalanine (Phe) to valine (Val) amino acid exchange in position 158 (Phe158Val), and (II) a C to T substitution (rs763361) within the DNAM-1 gene resulting with glycine (Gly) to serine (Ser) amino acid exchange in position 307 (Gly307Ser), as well as (III) a T to A substitution (rs1052248) in the 3′ UTR of the NCR3 gene. This evidence concerns the gene CD226 and rheumatoid arthritis.