Moreover, among 19 Hub-MHCsig, HLA-DMA, HLA-DMB, and HLA-DOA were positively correlated with microsatellite instability in colon adenocarcinoma, while TAP2, TAP1, and HLA-F were negatively correlated with microsatellite instability in testicular germ cell tumors (Fig. S3D). Here, TAP1 is linked to germ cell tumor.