CD8A and cancer: Then we analyzed the correlation between Hub-MHCsig and the abundance of immune cell infiltration in different cancer types and found that M1 macrophages, CD8 T cells, and regulatory T cells were positively correlated with the scores of Hub-MHCsig in all cancers while M0 macrophages, resting NK cells, and activated dendritic cells were negatively correlated with the scores of Hub-MHCsig in most cancers (Fig. S3B).