Two-year incident stroke probability was predicted by NOTCH3 variant risk category (hazard ratio HR-NOTCH3 vs MR-NOTCH3: 4.3, 95% CI 1.4–13.5, p = 0.011) and age (hazard ratio 1.6, 95% CI 1.1–2.4, p = 0.016), but not by sex and CVRFn (Figure 2). This evidence concerns the gene NOTCH3 and stroke disorder.