The HR-NOTCH3 group had a higher probability of 2-year incident stroke (hazard ratio 4.3, 95% CI 1.4–13.5, p = 0.011), and a higher increase in MSMD (β = 0.074, 95% CI 0.013–0.14, p = 0.017) and nLV (β = 0.14, 95% CI 0.034–0.24, p = 0.0089) than the MR-NOTCH3 group. The gene discussed is NOTCH3; the disease is stroke disorder.