BRCA2 and cancer: A common cancer variant, BRCA2 F2058Lfs*12 (c.6174delT), is cytosolic (58) and, in accordance with the PS3 criterion, annotated as the member of the ‘BRCA2 mutants (NLS)’ set (Figure 6F), in the disease reaction ‘Defective BRCA2 does not translocate to the nucleus’, belonging to the disease pathway ‘Defective homologous recombination repair (HRR) due to BRCA2 loss of function’ (60).