Employing nanocarriers constructed from DNA origami offers a sophisticated means for concurrently delivering DOX and various antisense components, such as antisense oligonucleotides (ASOs), B‐cell lymphoma 2 (Bcl2), and P‐glycoprotein (P‐gp), into cancer cells, thereby amplifying the effectiveness of cancer therapy. The gene discussed is PGP; the disease is cancer.