PGP and cancer: With these outstanding benefits, this biocompatible DNA origami platform has good potential to load oligonucleotides, and drugs for cancer therapy (Figure 5a).[75] Generally, one of the important roles of DNA origami structures, especially in MDR, is the co‐delivery of multiple therapeutic components.[76] Development of a multifunctional DNA origami platform via the mixture of DOX and GNRs t can be used to downregulate the expression of Pgp and avoid drug resistance of MCF7/ADR cells in vitro.