This revealed a partial overlap between proteomic profiles in AD relative to control, with an enrichment in both proteomes of amyloid‐associated proteins, that are related to the matrisome such as COL25A1, MDK, NTN1, SFRP1, SMOC1, HGF, SPOCK3, and reduction of neuronal‐specific proteins, including PCSK1, VGF, and NPTX2. This evidence concerns the gene SPOCK3 and Alzheimer disease.