Only 10 proteins of M89 overlapped with the previously identified Matrisome module (M42) in a consensus bulk proteome of AD brain,23 including SMOC1, NTN1, MDK, SFRP1, SLIT2, APP, APOE, NXPH1, TMEFF2, and SLIT1. Here, SLIT2 is linked to Alzheimer disease.