Pairwise comparison of AD to controls outlined a large fold increase in M89 “Matrisome/Heparin‐binding” proteins, such as SMOC1, MDK, C4B, SFRP1, and NTN1 with high specificity even as these proteins were not differentially expressed in the PSP versus control comparison. The gene discussed is SFRP1; the disease is Alzheimer disease.