PAPPA and Alzheimer disease: In the vascular fraction of AD, we observed significant increases in (i) several transport proteins (ATP7B, SLC4A11, APOF); (ii) proteins associated with the ECM (ADMATSL4, PAPPA, COL16A1); and (iii) transcription factors with pivotal roles in angiogenesis and vascular homeostasis (FLI1, POU3F, NFTAC2), were significantly increased.