ATP6AP2 and Alzheimer disease: Our vascular network featured five modules with overrepresentation of proteins from AD GWAS candidate loci, including M11 “ECM/Collagen fibril organization,” M67 “Mitochondria,” M77 “Laminin/Endothelial cell proliferation,” M89 “Matrisome/Heparin binding,” and M5 “Maintenance of BBB” (Figure 5A).