HLA-C and Alzheimer disease: Among these, six modules, including M11 “ECM/Collagen fibril organization”, M2 “Cell adhesion”, M77 “Laminin/Endothelial cell proliferation,” M88 “MHC complex,” M28 and M90 “Actin cytoskeleton/SMC contraction” demonstrated a significant enrichment with fibroblasts and SMCs and showed negative correlation with neuropathological traits, particularly CERAD and CAA score, reflecting the specificity of vascular changes in response to amyloid pathology in AD (Figures 2A and 3).