RCN1 and prostate carcinoma: For example, in prostate cancer cells, downregulation of RCN1 promoted apoptosis and necrosis of the cells [13]; in non-small cell lung cancer, high expression of the RCN1 protein was found to be significantly associated with poor prognosis in non-small cell lung cancer patients, and inhibition of RCN1 was shown to reduce proliferation, migration, and invasion of lung adenocarcinoma cells [12].