Treatment with MC-230078 at 10 mg/kg ameliorated T cell-induced colitis, and this reduction in colitis severity was associated with a significant decrease in colonic MPO levels (Fig. 7B) and a significant downregulation of the proinflammatory cytokines, IL-1β, IL-6, TNF-α, and IFN-γ compared with vehicle-treated mice (Fig. 7, C–G). The gene discussed is TNF; the disease is colitis.