Given that PINK1-mediated mitophagy is required for the survival of normal hematopoietic stem cells (HSCs) (34) and acute myeloid leukemia stem cells (35, 36), we hypothesized that a greater dependency on PINK1-mediated mitophagy upon stress may be the basis for the selective toxicity of GSK-3i to SRSF2P95H/+ cells. This evidence concerns the gene PINK1 and acute myeloid leukemia.