Comparable but significant results were obtained in human pancreatic islets from patients with obesity/T2D in 2 independent cohorts, without significant changes in the levels of GLP1R (Figure 2B; donor information in Supplemental Table 1; supplemental material available online with this article; https://doi.org/10.1172/JCI173214DS1). This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.