Despite the absence of incretin response both in Sucnr1-βKO mice and control mice in diet-induced obesity, β cells in Sucnr1-βKO mice fall short in counteracting hyperglycemia, which emphasizes the critical involvement of the succinate/SUCNR1 axis in this scenario. The gene discussed is SUCNR1; the disease is obesity due to melanocortin 4 receptor deficiency.