For these years, Clinical biomarkers like alpha-fetoprotein (AFP), lens culinaris agglutinin-reactive AFP (AFP-L3), and des-gamma-carboxyprothrombin (DCP) have been extensively utilized for the screening, diagnosis, and prognosis of HCC (Chen and Sharma 2020; Song et al. 2016). This evidence concerns the gene AFP and hepatocellular carcinoma.