FGF2 and dysplasia: We examined the expression of HBp17/FGFBP-1, FGF-2, and VEGF-A in surgically resected human tissues, including normal mucosa, hyperplasia, dysplasia of different degrees, and oral OSCC, by immunohistochemical analysis, and revealed that HBp17/ FGFBP-1, FGF-2, and VEGF-A expressions also increased with the severity of epithelial dysplasia, and their expression scores were highly correlated at all stages of the multistage development of SCC (Begum et al. 2007).