We examined the expression of HBp17/FGFBP-1, FGF-2, and VEGF-A in surgically resected human tissues, including normal mucosa, hyperplasia, dysplasia of different degrees, and oral OSCC, by immunohistochemical analysis, and revealed that HBp17/ FGFBP-1, FGF-2, and VEGF-A expressions also increased with the severity of epithelial dysplasia, and their expression scores were highly correlated at all stages of the multistage development of SCC (Begum et al. 2007). This evidence concerns the gene FGF2 and intraepithelial neoplasia.