NFKB1 and Familial prostate cancer: Bohonowych and colleagues investigated whether the extracellular heat shock protein 90α (eHSP90α) secreted by tumor cells might trigger a reactive matrix microenvironment and found its role in promoting prostate cancer progression via induction of inflammation through the activation of NF-kB and STAT3, including the transcription and secretion of proinflammatory cytokines IL-6 and IL-8 (Bohonowych et al. 2014).