Recently, studies showed that YAP binds to HIF-1α in the nucleus, sustaining HIF-1α protein stability to bind to PKM2 gene and directly activating PKM2 transcription to accelerate glycolysis under hypoxia stress [23], revealing the significant role of HIF-1 in hypoxia microenvironment of HCC. Here, YAP1 is linked to hepatocellular carcinoma.