PKM and hepatocellular carcinoma: Distinct from the previous two lncRNAs mentioned above, lncRNA LINC01554 was demonstrated downregulated in HCC, exerting as a novel tumor suppressor by promoting the ubiquitin-mediated degradation of pyruvate kinase isozymes M2 (PKM2) and inhibiting Akt/mTOR signaling pathway to abolish aerobic glycolysis in HCC cells [57].