On the other hand, Western blotting results showed that the ERK/CDC25C/CDk1/cyclinB1 pathway was inhibited in KIF22-knockdown MM cells, but activated in KIF22-overexpression MM cells (Fig. 3H), which indicated that KIF22 could regulate the ERK/CDC25C/CDk1/cyclinB1 pathway by transcriptional regulation of CDC25C. The gene discussed is CDK1; the disease is Miyoshi myopathy.