Cys106 serves asthe active-site residue for the enzymatic glyoxalase activity of PARK7,while oxidation of Cys106 is essential for PARK7 to accomplish nonenzymaticfunctions, including antioxidant, chaperone, cotranscription factor,and antiapoptotic/ferroptotic functions.7 On the other hand, the excessive oxidation of the Cys106 residueleads to the loss of its neuroprotective activity and the developmentof neurodegenerative diseases.8 The gene discussed is PARK7; the disease is neurodegenerative disease.