Since Na,K-ATPase was accumulated in regions of potential lysosomal localization, we used SW480 colon cancer cells with constitutive Wnt signaling resulting from a mutation of adenopolyposis coli (APC) (Faux et al., 2004) that had elevated levels of lysosomes (Clevers et al., 2014). The gene discussed is APC; the disease is colonic neoplasm.