SPP1 and fetal growth restriction: We identified 8 hub genes involved in PE, namely, PTGS2, ENG, KIT, MME, CGA, GAPDH, GPX3 and P4HA1, while the network of the PE + IUGR gene set included 9 hub genes, namely, PTGS2, FGF7, FGF10, IL10, SPP1, MPO, THBS1, CYBB and PF4 (Table 3).