The network of the PE + IUGR gene set included 9 hub genes, namely, PTGS2, FGF7, FGF10, IL10, SPP1, MPO, THBS1, CYBB and PF4, related to fibroblast growth factors, inflammation, chemotaxis and phagocytosis (Awamleh et al., 2019). The gene discussed is SPP1; the disease is fetal growth restriction.