Although several studies evaluated a larger number of MSA cases, they either did not report ADNC38,40,41 or reported only the mean or median values of Thal phases and Braak NFT stages for the pooled cohort13-15,42 or did not report the ADNC score suggesting the discrepancy of extent and severity between Aβ and tau pathology has been under-recognized. The gene discussed is MAPT; the disease is multiple system atrophy.