TARDBP and early-onset autosomal dominant Alzheimer disease: Next, we compared the Aβ pathology in Aβ-predominant ADNC-MSA with Alzheimer’s disease cases without α-syn, TDP-43 or vascular pathologies, using antibodies for various Aβ peptides in the temporal cortex and striatum (summarized in Supplementary Fig. 1 and Table 3).