APOE and multiple system atrophy: Figure 3B and C shows ADNC A and B scores in all APOE ɛ4 carriers (n = 61) and all APOE ɛ4 non-carriers (n = 82), respectively, suggesting the presence of APOE ɛ4 increases the baseline of the A score. Figure 3D and E depicts ADNC A and B scores in MSA APOE ɛ4 carriers (n = 8) and non-MSA APOE ɛ4 carriers (n = 53), respectively, indicating that the regression line is steeper in MSA than in non-MSA cases, which is supporting the observation of the discrepancy between A and B scores in our MSA cohort.