This distribution and severity of Aβ plaques and CAA pattern align with Type 3, as reported by Allen et al. 69 Previous studies have indicated that capillary CAA is strongly associated with the APOE ɛ4 allele and higher Thal phase.53,74 In line with these findings, three out of four genotyped Aβ-predominant ADNC-MSA cases (one case lacked genetic testing) carried the APOE ɛ4 allele. This evidence concerns the gene APOE and multiple system atrophy.