In the literature, only pooled data are available in connection to APOE genotypes, and a single case with APOE genotype (ɛ3/ɛ4) and Aβ pathology was reported.32 In our cohort, the MAPT haplotypes showed no association with Aβ-predominant ADNC-MSA cases, and the presence of pathogenic Alzheimer’s disease mutations in APP, PSEN1 or PSEN2 was excluded. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.