Immunostaining intensity using an AT8 antibody (pSer202 and pThr205) correlates with disease severity in tauopathy.9 PS19 mice start to exhibit an AT8 signal above baseline around 5 months of age in the hippocampus.49 We conducted immunohistochemistry and western blotting to evaluate the effect of Mark4 knockout on the abundance of the AT8 phospho-epitope in PS19 mice. Here, MARK4 is linked to tauopathy.