The higher sensitivity of CRP among men could at least partly be explained by sex differences in mycobacterial load, which many studies have largely attributed to delayed healthcare-seeking behavior.29,30 For men and people living in areas where time-to-TB diagnosis is delayed (populations expected to have higher mycobacterial load at diagnosis), our results suggest that CRP triage testing can be expected to detect the majority of those individuals with active TB who are at highest risk for poor outcomes from later TB diagnosis. This evidence concerns the gene CRP and tuberculosis.