C-reactive protein (CRP), a non-specific marker of inflammation, was recently recommended by World Health Organization (WHO) as a TB screening tool to facilitate intensified case finding among people living with HIV (PWH) based on multiple diagnostic accuracy studies and an individual patient meta-analysis.7 However, data on CRP as a triage test among all people with presumptive TB are limited and findings inconsistent. The gene discussed is CRP; the disease is tuberculosis.