IL13 and Alzheimer disease: Atopic disorders such as atopic dermatitis (AD), asthma, and food allergy are associated with T helper type 2 (Th2) cell responses, elevated production of the type 2 cytokines interleukin(IL)-4, IL-5, and IL-13, and induction of immunoglobulin(Ig)E1–4.Classically, this allergic inflammatory cascade is believed to originate with antigenic stimulation of T cell receptors on adaptive T cells, which in turn results in the production of IgE from B and plasma cells capable of binding the same antigen.