ACTA1 and Hepatic fibrosis: In dimethylnitrosamine (DMN)-induced mice livers, Juglone ameliorates liver fibrosis by reducing the expression of TGF-β1, α-SMA, and plasminogen activator inhibitor-I (PAI-1) through the downregulation of Erk-PI3K/Akt and p-Smad2/3 activation (Yang et al., 2014).