Similarly, Pin1 levels decrease following cadmium exposure in human hepatoma cells (HepG2) with an IC50 ≥ 6 μΜ, and the inhibition of Pin1 induces autophagy, likely through the upregulation of p-Ser-GSK3αβ (So and Oh, 2015). The gene discussed is PIN1; the disease is hepatocellular carcinoma.