The expression levels of regulatory factors related to cell and tumor invasion (CRNDE, EDN1, JUNB, MAP2K1/2) were significantly activated, among which the upstream regulatory factors CRNDE and EDN1 activated the expression of the downstream target EGFR to promote cell and tumor invasion, and JUNB activated PLAUR expression to promote cell and tumor invasion. The gene discussed is EGFR; the disease is neoplasm.