In the molecular regulatory network map in which NCAPD3 knockdown inhibits tumor cell proliferation and promotes tumor cell apoptosis, genes related to tumor cell proliferation pathways showed overall decrease or downregulation, among which CCND1, MYC, ESR1 were significantly decreased and their downstream genes CDK6 and IRS1 were significantly downregulated. The gene discussed is ESR1; the disease is neoplasm.