In the molecular regulatory network map, in which NCAPD3 knockdown inhibited tumor cell proliferation and promoted tumor cell apoptosis, genes related to tumor cell proliferation pathways showed overall inhibition or downregulation, among which CCND1, MYC, and ESR1 were significantly inhibited and their downstream genes CDK6 and IRSI were significantly downregulated. This evidence concerns the gene ESR1 and neoplasm.