RIG-I was shown to be the major PRR that sensed the infection of LACV, RVFV and SFTSV to induce innate immune response, as evidenced by decreased IFNs and ISGs induction in RIG-I-depleted cells (Habjan et al., 2008; Verbruggen et al., 2011; Weber et al., 2013; Min et al., 2020). The gene discussed is RIGI; the disease is infection.