Through single-cell transcriptomic sequencing, we discovered that the monocyte_C02 subpopulation is more prevalent in right-sided colorectal cancer, and its highly expressed genes, such as CXCL8, TNFAIP6, CXCL3, and SPP1, may be implicated in tumor growth promotion. Here, TNFAIP6 is linked to neoplasm.