In Figure 5A, using the ebi-a-GCST90018808 dataset from the GWAS database for the forward MR analysis indicated a high positive correlation between genetic variation in LUCAT1 and the risk of developing colorectal cancer (ORwr = 2.8365 [1.6750–4.8035], p = 0.0001), signifying a notable elevation in cancer risk. Here, LUCAT1 is linked to colorectal cancer.