Using these genes as exposure factors and employing bioinformatics methods like Mendelian randomization, colocalization, and directional filtering, we discovered that genetic variations in LUCAT1, a long-chain non-coding RNA, are risk factors for right-sided CRC, potentially linked to the single-nucleotide polymorphism (SNP) rs10774624. Here, LUCAT1 is linked to colorectal carcinoma.