The modification of cadherin (E-cadherin) by β1,6 N-acetylglucosaminyltransferase V (GnT-V), which adds β1,6-N-acetylglucosamine (β1,6GlcNAc)-branched N-glycans, impairs cell adhesion and aids in tumor cell invasion. The gene discussed is CDH17; the disease is neoplasm.