Given that 36% (9/25 variants) of HS cases reported in the literature is related to variants located in exon 6 of the SLC29A3 gene (Bolze et al., 2012; Al-Haggar et al., 2015), a targeted variant screening of this mutational hotspot was conducted by Sanger sequencing. The gene discussed is SLC29A3; the disease is histiocytic sarcoma.