Hyperpigmentation, hypertrichosis, chronic urticaria, dermis fibrosis, moderate interstitial and perivascular inflammatory infiltrate extended to the hypodermis composed of histiocytes, lymphocytes and plasma cells (CD68+), cardiac disease, hallux valgus, bilateral camptodactyly of the toes, osteoarticular abnormalities: unilateral right sacroiliitis of inflammatory origin, inflammatory arthralgias with arthritis of both wrists and left knee, hyperthyroidism. This evidence concerns the gene CD68 and heart disorder.