Hyperpigmentation, hypertrichosis, dermis fibrosis, cardiac disease: concentrically enlarged left ventricle, moderate pericardial effusion, hallux valgus, bilateral camptodactyly of the toes, ankylosing spondylitis associated with an osteoarticular disorder, moderate inflammatory syndrome, lympho-histiocytic infiltration (CD68+) of soft tissues, hepatosplenomegaly, diabetes mellitus, hypoplasia of right kidney, hypogonadism. Here, CD68 is linked to diabetes mellitus.