Overexpression of circ_0003945 in NSCLC cells increased MMP9 and Fibronectin, reduced E-Cadherin via KLF4 and miR-3182, and activated Rac1/FAK1/MMP2 and JNK/MAPK pathways, promoting migration and invasion (51). Here, KLF4 is linked to non-small cell lung carcinoma.