Analyses of circ_0003945-medicated ceRNA network in PAAD, via the Gene Expression Omnibus database, highlighted its influence on key pathways (NF-κB, PI3K-Akt, Wnt) and immune cell infiltration through the miR-494 axis and hub genes (CXCR4, HIF1A, ZEB1, and SDC1) (53). Here, CXCR4 is linked to pancreatic adenocarcinoma.